The Center for Medical Cannabis Research, an organization, sanctioned by state and federal oversight committees, conduct research on the possible medical applications for marijuana and cancer. A recent double-blind controlled study of smoked placebo versus smoked marijuana in patients with cancer-derived chronic peripheral neuropathic pain found that 10 of the 16 patients they studied experienced a 30% reduction in pain after seven days of smoking cannabis. The study used a capsaicin based pain model, meaning that the pain felt from the subjects was due to heat or a burning sensation. The study not only produced valuable data on marijuana and cancer-induced pain, but it also paves a road to examining other ways in which cannabis can be used for analgesic effects.
The potential medical applications of the CB1 and CB2 receptors are growing exponentially, and the appeal of using something natural over synthetic pharmaceuticals is becoming more desirable by society. The endocannabinoid system is essential to the life and death cycle of cells, proving a link between marijuana and cancer’s central operating mechanism. Cancer patients who benefit from the smoking of marijuana should not be denied the right to protect their life. The use of marijuana to treat cancer is a medical issue, to be discussed between a qualified doctor and their patient, not a legal one.
If you are looking to find relief from symptoms of cancer and side effects of cancer treatments medical marijuana can help
Cancer and Marijuana Cannabinoids
The active molecular components in marijuana, known as the cannabinoids, are known to have neuroprotective and analgesic (pain relief) effects. Delta-9-tetrahydrocannabinol, or THC, is the cannabinoid that many cannabis researchers have focused on in the past several decades of studies of marijuana and cancer-related ailments. However, many medical marijuana patients and physicians believe that the purified form of THC or its synthetic counterparts is not as effective as orally consuming foods (edibles) or liquids (tincture) made with cannabis or the smoking of the buds on the marijuana plant. It is possible that the marijuana plant’s multitude of different natural cannabinoids provides an increased therapeutic effect as opposed to a single synthetic cannabinoid.
Cannabinoids have also been researched for their possible use in cancer prevention and cancer treatment. Cancer is most notably defined by the multiplication of mutated somatic cells in the body. The mutated cells have damaged DNA that was not copied correctly during cell division. Cancer cells multiply more rapidly than normal cells and often have altered functions due to the cells’ mutated genetic code. Cannabinoids have been proven to stimulate the apoptotic pathway in cells, which is the programmed death of a cell that has acknowledged that it is no longer functioning efficiently. In this way, marijuana can actively prevent tumor growth by signaling cancerous cells to “commit suicide.” Also, the cannabinoid receptors arrest the G1 (Growth 1) phase of the cell cycle. This ultimately prevents the cancer cell from maturing any further which would inhibit the amount of harmful toxins created by the cancer cell.
The CB1 receptors also prevent inflammation in other parts of the body as an effect of the marijuana use with individual cancer patients suffering from inflammation. These were some of the first implications that suggested that the cannabinoid receptors activated by marijuana and cancer could help prevent cancer cell inflammation and nerve pain associated with inflammatory response in cells.